Interstate 94, the State’s major east-west artery, bisects the City, providing direct access to Battle Creek, Jackson and Detroit to the east, and St. Joseph and Chicago to the west. U.S. 131 is the City’s principal north-south highway, providing direct access to Grand Rapids. Other major highways providing access across the City and the County include M-89, M-43, and M-96.

Four major airlines provide daily air service from Kalamazoo-Battle Creek International Airport to several hubs throughout the country including Detroit, Chicago, Minneapolis, Atlanta and Cincinnati. Plans to expand the capacity of the airport are underway.  Amtrak provides passenger rail service, while Norfolk Southern and CN North America provides freight service to the area.

Intra-city bus transportation is provided by the City’s Metro Transit system while Greyhound and Indian Trails bus lines provide transportation for the area. In 2006, the City officially opened the new Kalamazoo Downtown Transportation Station, which houses all ground transportation for the area. In November, 2006 citizens passed a millage that would support the expansion of the City’s transportation system to include the County. Plans are underway to transition the City’s local bus service into a regional transportation system.  
 
Metro Transit ridership trends have fluctuated since 2001. According to the 2003 Kalamazoo Area Transportation Study, 38.35% of Metro Transit passengers are considered "captive" riders versus "choice" riders. Captive riders are those passengers who have no driver's license, no automobile available in their household or no other alternative means of personal transportation.